Thursday, August 4, 2011

English Lessons

Free English Poetry
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The Cord
Leanne O’Sullivan
I used to lie on the floor for hours after
school with the phone cradled between
my shoulder and my ear, a plate of cold
rice to my left, my school books to my right.
Twirling the cord between my fingers
I spoke to friends who recognized the
language of our realm. Throats and lungs
swollen, we talked into the heart of the night,
toying with the idea of hair dye and suicide,
about the boys who didn’t love us,
who we loved too much, the pang
of the nights. Each sentence was
new territory, like a door someone was
rushing into, the glass shattering
with delirium, with knowledge and fear.
My Mother never complained about the phone bill,
what it cost for her daughter to disappear
behind a door, watching the cord
stretching its muscle away from her.
Perhaps she thought it was the only way
she could reach me, sending me away
to speak in the underworld.
As long as I was speaking
she could put my ear to the tenuous earth
and allow me to listen, to decipher.
And these were the elements of my Mother,
the earthed wire, the burning cable,
as if she flowed into the room with
me to somehow say, Stay where I can reach you,
the dim room, the dark earth. Speak of this
and when you feel removed from it
I will pull the cord and take you
back towards me.

English Lessons

Hi, and welcome to American English Conversation online courses. Here you can find free, quality English Lessons for all type of studets. Our English Lessons are comprehensive and great for individuals trying to enhance there English. English lessons are one on one and group lessons. American English converstion course is FREE for all that want free English lessons. English Lesson to help and instruct with English conversation. English lesson are concentrated around our student individual needs. English lesson will help you improve your spoken English. Our English Lessons can help you achieve a great knowledge of the English language. With our English lessons you will see your self improve greatly. English Lessons, English Lessons.An exciting learning environment, the courses are accuracy-based approach is also met through a systematic approach to learning English. At American English Conversation our individual courses have helped thousands of students from all around the world gain experience in English conversation and vocabulary skills
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LOS ANGELES (AP) -- Bank of America Corp. is close to finalizing a deal to pay $8.5 billion to settle claims by a group of blue-chip investors that the bank sold them poor-quality mortgage-backed securities that went sour when the housing market tanked, according to a person familiar with the settlement talks.
The Charlotte, N.C., bank was continuing talks late Tuesday with the group, which includes the Federal Reserve Bank of New York, Pimco Investment Management, the world's largest bondholder, and Blackrock Financial Management. It is expected to announce an agreement as early as Wednesday, the person said on condition of anonymity because the matter was still developing.
The deal comes eight months after the group fired off a letter to Bank of America demanding that it repurchase $47 billion in mortgages that its Countrywide unit sold to them in the form of bonds. The investors have argued that Countrywide's practice of modifying loans found to have faulty paperwork or those written outside of normal underwriting standards breached signed agreements with the investors. By continuing to service bad loans rather than speeding up foreclosures, the group has claimed that Countrywide ran up servicing fees, enriching itself at the expense of investors. The New York Fed is involved because it took over assets held by American International Group Inc., which faltered under the weight of bad home loans that it insured.
Bank of America, which paid $4 billion for Countrywide in 2008, has dismissed suggestions that its handling of loan modifications and other efforts to prevent foreclosure have violated the terms of the mortgage-backed securities that the investors hold. In November, CEO Brian Moynihan said he was in day-to-day "hand-to-hand combat" with investors' demands.
But the combined effect of the Countrywide deal, mortgage crisis and the risk overhang of the soured loans have been a drain on BofA's bottom line and stock price, eventually prompting a reversal in strategy. Since the beginning of the year, the bank has struck large settlements with multiple investors. In January, the lender paid $2.6 billion to settle buyback claims on home loans sold to Fannie Mae and Freddie Mac. And in April, the bank agreed to pay up to $1.6 billion to Assured Guaranty Ltd., an insurer that also pressed the bank to repurchase shoddy mortgages. If approved, the latest settlement would address a significant remaining slice of Bank of America's mortgage buyback claim risk.
A Bank of America spokesman could not immediately be reached for comment.
Shares of Bank of America gained 14 cents, or 1.3 percent, to $10.96 in aftermarket trading on Tuesday. The shares had closed the regular session down 3 cents at $10.82.

Bank of America Corp. is close to finalizing a deal to pay $8.5 billion to settle claims by a group of blue-chip investors that the bank sold them poor-quality mortgage-backed securities?
A. TRUE
B. FALSE

A Bank of America spokesman could not immediately be reached for comment. Shares of Bank of America gained 14 cents, or 1.3 percent, to $10.96 in aftermarket trading on Tuesday?
A. TRUE
B. FALSE

English Lessons

Hi, and welcome to American English Conversation online courses. Here you can find free, quality English Lessons for all type of studets. Our English Lessons are comprehensive and great for individuals trying to enhance there English. English lessons are one on one and group lessons. American English converstion course is FREE for all that want free English lessons. English Lesson to help and instruct with English conversation. English lesson are concentrated around our student individual needs. English lesson will help you improve your spoken English. Our English Lessons can help you achieve a great knowledge of the English language. With our English lessons you will see your self improve greatly. English Lessons, English Lessons.An exciting learning environment, the courses are accuracy-based approach is also met through a systematic approach to learning English. At American English Conversation our individual courses have helped thousands of students from all around the world gain experience in English conversation and vocabulary skills
If you would like to brush-up your English conversation knowledge, review outside of class or increase your English skills this is the course for you. Subscribe to American English Conversation course for FREE.
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LOS ANGELES (AP) -- Bank of America Corp. is close to finalizing a deal to pay $8.5 billion to settle claims by a group of blue-chip investors that the bank sold them poor-quality mortgage-backed securities that went sour when the housing market tanked, according to a person familiar with the settlement talks.
The Charlotte, N.C., bank was continuing talks late Tuesday with the group, which includes the Federal Reserve Bank of New York, Pimco Investment Management, the world's largest bondholder, and Blackrock Financial Management. It is expected to announce an agreement as early as Wednesday, the person said on condition of anonymity because the matter was still developing.
The deal comes eight months after the group fired off a letter to Bank of America demanding that it repurchase $47 billion in mortgages that its Countrywide unit sold to them in the form of bonds. The investors have argued that Countrywide's practice of modifying loans found to have faulty paperwork or those written outside of normal underwriting standards breached signed agreements with the investors. By continuing to service bad loans rather than speeding up foreclosures, the group has claimed that Countrywide ran up servicing fees, enriching itself at the expense of investors. The New York Fed is involved because it took over assets held by American International Group Inc., which faltered under the weight of bad home loans that it insured.
Bank of America, which paid $4 billion for Countrywide in 2008, has dismissed suggestions that its handling of loan modifications and other efforts to prevent foreclosure have violated the terms of the mortgage-backed securities that the investors hold. In November, CEO Brian Moynihan said he was in day-to-day "hand-to-hand combat" with investors' demands.
But the combined effect of the Countrywide deal, mortgage crisis and the risk overhang of the soured loans have been a drain on BofA's bottom line and stock price, eventually prompting a reversal in strategy. Since the beginning of the year, the bank has struck large settlements with multiple investors. In January, the lender paid $2.6 billion to settle buyback claims on home loans sold to Fannie Mae and Freddie Mac. And in April, the bank agreed to pay up to $1.6 billion to Assured Guaranty Ltd., an insurer that also pressed the bank to repurchase shoddy mortgages. If approved, the latest settlement would address a significant remaining slice of Bank of America's mortgage buyback claim risk.
A Bank of America spokesman could not immediately be reached for comment.
Shares of Bank of America gained 14 cents, or 1.3 percent, to $10.96 in aftermarket trading on Tuesday. The shares had closed the regular session down 3 cents at $10.82.

Bank of America Corp. is close to finalizing a deal to pay $8.5 billion to settle claims by a group of blue-chip investors that the bank sold them poor-quality mortgage-backed securities?
A. TRUE
B. FALSE

A Bank of America spokesman could not immediately be reached for comment. Shares of Bank of America gained 14 cents, or 1.3 percent, to $10.96 in aftermarket trading on Tuesday?
A. TRUE
B. FALSE

Wednesday, August 3, 2011

English Lessons

DIRECTIONS: Read the following and answer all the questions?
http://www.americanenglishconversation.com/
http://www.freeenglishconversation.blogspot.com/
http://www.grammar-help.blogspot.com/

ALLENTOWN, Pa. (AP) -- Two unexpected gushers in northeastern Pennsylvania are helping to illustrate the enormous potential of the Marcellus Shale natural gas field.
Each of the Cabot Oil & Gas Corp. wells in Susquehanna County is capable of producing 30 million cubic feet per day -- believed to be a record for the Marcellus and enough gas to supply nearly 1,000 homes for a year. The landowners attached to the wells, who leased the well access, numbering fewer than 25, are splitting hundreds of thousands of dollars in monthly royalties.
"There was definitely excitement among the team that planned out these wells and executed their completion," said Cabot spokesman George Stark.
Drilling companies knew the Marcellus held a lot of gas. They just had to figure out a way to get it out, and they say they're getting better at it all the time.
The result is that the Marcellus, a rock formation beneath Pennsylvania, New York, West Virginia and Ohio, has turned out to be an even more prolific source of gas than anyone anticipated. Energy firms are boosting their production targets, not only because new wells are coming on line but also because they're managing to coax more gas from each well.
Operators say they have a greater understanding of the complicated geology of the Marcellus, allowing them to land their drill bits in the sweet spot of the formation. They're drilling horizontally at greater distances, giving them access to more of the gas locked within the rock. And they're tweaking how they break apart the shale.
"It's like batting practice," said Matt Pitzarella, spokesman for Range Resources Corp. "The more you swing the bat, the better you get."
Fort Worth, Texas-based Range has boosted its estimate of the amount of natural gas it will ultimately be able to harvest from its Marcellus Shale wells, telling investors this month that it plans to triple production to 600 million cubic feet per day by the end of 2012.
Another major player, Chesapeake Energy Corp., has likewise reported a dramatic increase in expected well production. Early on, the Oklahoma City-based driller predicted that each well would yield 3.5 billion cubic feet of gas over its life span. That amount has since doubled, to more than 7 billion cubic feet, and continues to go up.
"Growing confidence in reserve quality is a major reason why many of the largest, most-successful, domestic and international energy companies are heavily investing in the Marcellus and other American shale plays," said Jeff Fisher, Chesapeake's senior vice president of production.
Indeed, major oil companies like Chevron Corp., Exxon Mobil Corp. and Royal Dutch Shell PLC have placed multibillion-dollar bets on the Marcellus, a 400-million-year-old rock formation that geologists say holds the nation's largest reservoir of natural gas and perhaps the second-largest in the world.
To unlock the shale's riches, drillers combine horizontal drilling with hydraulic fracturing, a technique known as fracking that pumps millions of gallons of water, along with sand and chemicals, into the well to creature fissures in the rock and allow natural gas to flow up. Fracking has raised environmental concerns, and the U.S. Environmental Protection Agency is studying its impact on groundwater. The industry insists the process is environmentally safe.
The technology has unleashed a drilling frenzy in Pennsylvania -- where more than 3,300 Marcellus wells have been sunk the past few years -- and accounts for a twelvefold increase in U.S. shale gas production since 2000. Gas harvested from the Marcellus and other shale fields around the country -- including the Barnett Shale in Texas and the Haynesville Shale in Louisiana -- now represents a quarter of total U.S. natural gas production.
The new Cabot wells help illustrate why boosters believe the gas field could help steer U.S. energy policy for decades to come. They were also a nice bit of good news for Cabot, the Houston-based driller that endured two years of bad publicity after state regulators accused it of polluting water supplies in Dimock Township, Susquehanna County.
The wells -- also located in Dimock -- are "producing like gushers," exulted Stark, the Cabot spokesman, helping to push the company's daily production above 400 million cubic feet per day.
Like other drillers, Cabot has steadily increased the horizontal length of its wells, from an average of 2,100 feet in 2008 to 3,600 feet last year. It has seen a corresponding increase in capacity.
Capacity, though, does not always translate to production.
Cabot's wells, and Marcellus wells in general, are not running at full tilt, mainly because the infrastructure required to take the gas from wellhead to market is not yet fully in place. An oversupply of natural gas and the availability of crews to fracture the wells are other limiting factors.
"We certainly have had to manage our pace of drilling with the installation of pipeline infrastructure and demand in the market," Chesapeake's Fisher said in a statement. "While some delays in production startups are common in the early phase of these large-scale plays, the industry is working hard to build the infrastructure that will enable Marcellus reserves to get to market for decades to come."
The Marcellus isn't the only shale formation in Pennsylvania that energy companies have their eye on. Drillers are just beginning to explore the gas-bearing Utica and Upper Devonian formations. The Utica is deeper that the Marcellus, and the Upper Devonian is shallower.
"It's triple the resource potential under the same plot of land," said Kevin Cabla, an energy analyst at Raymond James & Associates.
NEW YORK (AP) -- A member of a publicity-seeking hacker group that sabotaged websites over the past two months and is dissolving itself says his group isn't disbanding under pressure from the FBI or enemy hackers.
"We're not quitting because we're afraid of law enforcement," the LulzSec member said in a conversation with The Associated Press over the Internet voice program Skype. "The press are getting bored of us, and we're getting bored of us."
The group's hacking has included attacks on law enforcement and releases of private data. It said unexpectedly on Saturday it was dissolving itself.
In the Sunday interview, the hacker acknowledged that some of the material being circulated by rivals online -- which purports to reveal the hackers' online nicknames, past histories, and chat logs -- was genuine, something he said had proved to be "a distraction."
He added that three or four of Lulz Security's members were taking what he called "a breather" and said he was considering giving up cyberattacks altogether.
"Maybe I'll stop this hacking thing entirely. I haven't decided," he said. He said he couldn't speak for the others' long-term plans, but said it was possible some of the members would continue to be involved with Anonymous, the much larger and more amorphous hacking group which has targeted the Church of Scientology, Middle Eastern dictatorships, and the music industry, among others.
He said the six-member group was still sitting on a considerable amount of stolen law enforcement files.

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, On Wednesday August 3, 2011, 5:35 pm EDT
WASHINGTON (AP) -- Shoppers won't shop. Companies won't hire. The government won't spend on economic stimulus -- it's cutting instead. And the Federal Reserve is reluctant to do anything more.
Without much to invigorate growth, the economy may be in danger of slipping into a stupor like the one Japan has failed to shake off for more than a decade. And Wall Street is spooked.
The Dow Jones industrial average Wednesday barely broke an eight-day losing streak, finishing up about 30 points. A nine-day losing streak would have been the Dow's first since February 1978.
Even with the gain, the Dow has fallen 828 points, or 6.5 percent, over the past nine trading days. Investors didn't even pause to celebrate the resolution over the weekend of a dangerous debt standoff in Washington.
Stunned by news last week that the economy barely grew in the first half of 2011, economists are lowering their forecasts for the full year and recalculating the odds that the economy will slide back into recession.
Kurt Karl, chief U.S. economist at Swiss Re, has cut his 2011 forecast for growth this year to 1.8 percent from 2.6 percent. And he has bumped up the likelihood of another recession to 20 percent from 15 percent.
"The last week has made it much more likely that corporate profit estimates will be revised lower," said Nick Kalivas, a vice president of financial research at MF Global.
The stocks that have fallen the furthest have been those of companies that fare best in economic expansions. Industrial companies like Caterpillar and Boeing, energy companies like Exxon Mobil and Chevron, and retailers like Amazon and Coach have all fallen by more than the broader stock market.
Investors have pushed government bond yields to their lowest level of the year. The 10-year Treasury note now yields 2.6 percent. Bond yields typically fall when the economy is weak because nervous investors view bonds as a safe place to park their money, and there's less chance that inflation will erode their value.
The economy started sputtering early in the year. Economists at first thought the slowdown would be temporary, the result of a short-term rise in gasoline prices and an earthquake in Japan that disrupted shipments of auto parts and electronics.
But the weakness persisted. And it worsened as a political fight over debt and deficits raised the risk that the U.S. government would not be able to pay all its bills.
"It now seems fairly clear that those shocks have done a lot more damage than we expected," says Leo Abruzzese, global forecasting director for the Economist Intelligence Unit. "They seem to have had a devastating effect on confidence."
After the government reported that the economy grew at an annual pace of 0.4 percent in the first quarter and 1.3 percent in the second, Abruzzese is cutting his estimate for 2011 growth from 2.4 percent to less than 2 percent.
It's hard to see anything lifting growth to the 2.5 percent needed to keep unemployment from rising, let alone the 5 percent needed to bring the rate down significantly from June's 9.2 percent.
"Sales are what keeps the market moving higher, and there's not much demand when there's only 0.4 percent growth," said Andrew Goldberg, U.S. market strategist at JP Morgan Funds.
When the economy grows less than 2 percent over a 12-month period, it risks slipping into recession, says Mark Vitner, senior economist at Wells Fargo Securities. Over the most recent such period, the economy grew just 1.6 percent.
Few economists are predicting another recession, despite a series of weak economic reports. Gasoline prices have come down from their high of almost $4 a gallon in May. And Japanese factories are starting to crank up again after the March earthquake.
At the heart of the economy's problems are the debts that consumers built up during the early and mid-2000s. Many borrowed against the equity in their homes, convinced that house prices would rise forever.
When housing prices collapsed, people were left owing more than their homes were worth. Others charged up their credit cards. Now it's payback time, and Americans are spending less or spending cautiously as they slash their debts.
Companies are reluctant to hire until they're convinced enough customers are ready to buy their products or services. Corporate profits are booming, though, because companies laid off millions of workers, learned to operate more efficiently with smaller staffs and expanded in growing markets overseas.
"If companies were inclined to hire, they could," Abruzzese says.
So companies are waiting for consumers to spend, and consumers are waiting for companies to hire them or offer generous pay raises and job security. It's a tough cycle to break.
In the past, the government has helped by spending on infrastructure projects or jobs programs. This time, it's cutting at all levels. In the second quarter, government cutbacks reduced economic growth by 0.2 percentage points.
More cuts are coming. The deal to raise the debt limit calls for $917 billion in federal spending cuts. Those won't do much immediate damage to the economy because they mostly kick in after 2013, but a special congressional committee is supposed to find at least another $1.2 trillion in savings over the next decade, and no one knows where the ax will fall.
"You're not sure if there are going to be huge spending cuts or tax increases. Or are they just going to wrangle?" Swiss Re economist Karl says. "If you're a supplier to any part of the government, you certainly are not rushing to hire people or buy equipment. There's definitely a damper on growth."
To some economists, the United States is starting to look eerily like Japan. The Japanese economy fell into a recession in the early `90s. It has never fully returned to health, largely because of policy mistakes. The government raised taxes after declaring victory over the downturn prematurely. And U.S. economists, including current Fed Chairman Ben Bernanke, criticized the Japanese central bank, the Bank of Japan, for being too passive to turn the economy around.
The Fed has kept short-term interest rates near zero since December 2008 to stimulate the economy. But at the end of June, it ended a $600 billion program to buy government bonds and keep long-term rates -- the ones that determine the rates people pay on cars and houses -- low.
It was the second round of what economists call quantitative easing, or QE2 for short. But the Fed has no plans for a third, fearing it would lead to higher inflation.
Kenneth Rogoff, a Harvard University economist, says that in this economy, QE3 -- and, if necessary, QE4 and beyond -- is the only hope.
"Yes, we are starting to look like Japan," he says. "But it is not too late."
Randall reported from New York.
"It's safe to say at this point that they are sitting on a lot of data."
Although the hacker declined to identify himself publicly, he has verified his membership with Lulz Security by posting a pre-arranged message to the group's popular Twitter feed.
Lulz Security made its Saturday announcement about disbanding through its Twitter account. That statement gave no reason for the disbandment.
One of the group's members was interviewed by The Associated Press on Friday, and gave no indication that its work was ending. LulzSec claimed hacks on major entertainment companies, FBI partner organizations, the CIA, the U.S. Senate and a pornography website.
Kevin Mitnick, a security consultant and former hacker, said the group had probably concluded that the more they kept up their activities, the greater the chance that one of them would make some mistake that would enable authorities to catch them. They've inspired copycat groups around the globe, he noted, which means similar attacks are likely to continue even without LulzSec.
"They can sit back and watch the mayhem and not risk being captured," Mitnick said.
As a parting shot, LulzSec released a grab-bag of documents and login information apparently gleaned from gaming websites and corporate servers. The largest group of documents -- 338 files -- appears to be internal documents from AT&T Inc., detailing its buildout of a new wireless broadband network in the U.S. The network is set to go live this summer. A spokesman for the phone company could not immediately confirm the authenticity of the documents.
In the Friday interview, the LulzSec member said the group was sitting on at least 5 gigabytes of government and law enforcement data from across the world, which it planned to release in the next three weeks. Saturday's release was less than a tenth of that size.
In an unusual strategy for a hacker group, LulzSec has sought publicity and conducted a conversation with the public through its Twitter account. LulzSec attacked anyone it could for "the lulz," which is Internet jargon for "laughs."
Satter contributed from London.

Two unexpected gushers in northeastern Pennsylvania are helping to illustrate the enormous potential of the Marcellus Shale natural gas field?
A. TRUE
B. FALSE

In an unusual strategy for a hacker group, LulzSec has sought publicity and conducted a conversation with the public through its Twitter account. LulzSec attacked anyone it could for "the lulz," which is Internet?
A. TRUE
B. FALSE

English Lessons

DIRECTIONS: Read the following and answer the questions?
http://www.americanenglishconversation.com
http://www.freeenglishconversation.blogspot.com/
http://grammar-help.blogspot.com/
http://freeenglishlessons-denise.blogspot.com/

For two decades, researchers hoped it might be possible to create a vaccine that teaches the body’s sentries, called dendritic cells, to recognize cancer, and then spur the immune system’s infantry, the T-cells, to attack the tumor. But every drug company that tried the approach failed — until last year. That’s when Seattle-based Dendreon got approval from the Food and Drug Administration to market its vaccine, Provenge, as a treatment for prostate cancer that has spread but is not causing symptoms like bone pain.
David Urdal, who served at Dendreon’s chief scientific officer for 16 years, is one of the key figures in that victory. Before Dendreon, he was head of manufacturing at Immunex, the pioneering Seattle biotech firm that was bought by Amgen for $16 billion in 2001. With Provenge having finally reached patients and with the company beginning to overcome the manufacturing challenges that have limited its sales, Urdal recently announced his decision to retire.
I sat down with Urdal to talk about how Provenge got to market – and about his hopes for the future of medicine. Points of interest: Urdal started working with Dendreon’s former chief executive, Chris Henney, shortly after getting his PhD.; he says the FDA might have made the right decision by rejecting Provenge in 2007, and later approving it; and he worries that biotech is getting too risky for venture capitalists. This interview has been edited for length and clarity.
Matt Herper: How is it that you came to Dendreon? You already knew the company’s chief executive.
David Urdal: I was first approached by the man who was to become the CEO, Chris Henney, in 1994, and he asked me to look at this opportunity. Ev I was in post-doctoral fellowship in [Henney's] lab at the Fred Hutchinson Cancer Center. This was the late ’70s. That was when he and [Steve] Gillis founded Immunex Corporation and he recruited me to Immunex back in 1980-81 or whenever that was. And so I started working at Immunex as a scientist.
Matt Herper: Before Chris Henney was involved, Dendreon had been founded by two Stanford researchers, and had gone through a rough patch. What made the opportunity interesting to you?
David Urdal: Their names were Ed Engleman and Sam Strober, and the technology that was of particular interest to me and ultimately to Chris was the work that Ed Engleman was doing with the blood-derived dendritic cell, a type of immune cell. The company had originally been funded by Healthcare Ventures, and they had run through their first $10 million since founding two years earlier and Chris was faced with the challenge of the need to re-capitalize the company. We needed to put it on a path that would allow us to take the company public and have a more of a commercial focus.
The company initially had one piece of intellectual property and it was a device that could allow you to separate cells by buoyant density that was being applied at that time to the isolation of [blood] stem cells for stem cell transplantation. And Chris and I looked at that and go well geez, at that time we would have been the third of fourth company looking at stem cell isolation and transplantation.
But it was showing promise in these early first-in-human studies in cancer that Engleman was doing with Ron Levy. So we had a way of marrying the device that the company was working with a novel cell line that had the potential to really address some major unmet needs in cancer.
Matt Herper: And why did you choose prostate cancer? Other cancer vaccine companies focused on melanoma and blood cancers.
David Urdal: Well, two reasons really. The model that we were working in could find ways to induce immunity to the [prostate] gland. If we could do that consistently that we could potentially treat malignancies derived from that gland. And the second was just a back of the envelope opportunity analysis. It’s a huge unmet need. Prostate cancer is the second leading cause of cancer and mortality in men and we knew we’d have to spend hundreds of millions of dollars anyway. Might as well do it that setting as opposed to doing it in, I don’t know, one of the other cancers that at the time would have been more favored.
Matt Herper: Speeding forward a decade: Why did you decide to file for approval, FDA approval, that first time, given that the studies had missed their primary endpoints and that a third study, the IMPACT trial, was already going on?
Urdal: It was really the nature of the data and how strong the evidence was that we were actually having an impact on survival. We had a really important meeting with the FDA in 2005 at which we shared with them the survival results and the analyses that we’d done. We were really up front with them, we said, look we didn’t specify overall survival as a primary endpoint of the study but we followed every patient for three years and these are the results that we obtained. And all of the analysis, all of the analyses that we’d done, you know, we can’t another explanation for the outcome that we saw except that these men received [Provenge.]
The key outcome from that 2005 meeting was a very a clear: “We, the FDA, find the results provocative and we could do a review.” And we went out and we built out the first phase of the manufacturing plant in 2006 and completed our license application in 2006 and it was accepted for review in January 2007. Then we had our famous advisory committee meeting in 2007.
Matt Herper: That advisory committee voted that Provenge should be approved. But the FDA rejected it in May 2007. Were you surprised by that rejection?
David Urdal: Well, I thought the advisory committee went incredibly well for us. I mean it got all the data that reflected up to that time and we got an incredibly positive reception. We had a unanimous vote on safety.
Matt Herper: But there was a real split between the opinons of the oncologists, who had doubts, and the cell therapy folks, who were enthusiastic.
David Urdal: Of the four votes against approval at that time, two were members of the [Oncology Drugs Advisory Committee] that had been invited to participate in the meeting. And it was clear, when I look back on it now, that even though the vote came out in our favor, there also was a sentiment that was expressed during the course of that day where all parties found the results provocative but hoped that there would be a way that meaningful data could be obtained from the ongoing study, IMPACT, that everyone knew was still enrolling patients and would still have some follow-up period to go. And I think in the end that’s what drove the FDA making the decision that they did — that look, these results are compelling, but we don’t see that we can be assured that we’d get meaningful data that would support the efficacy claim if we were to approve it in 2007. And they might have been right.
But it wasn’t just them, I think if you follow the sentiments within the clinical community I think there was a sense of, okay, if it’s approved I’d probably prescribe it, but geez, it’s a small study, overall survival wasn’t the primary endpoint, there wasn’t a sense of enthusiasm for it, and I think in the end of course the IMPACT study results came back and this completely vindicated the results from the earlier trials.
Matt Herper: Why do you think it is that time to progression, the time it takes for the tumor to start growing, wasn’t affected by Provenge, but people lived longer? To a lot of people, that doesn’t make biological sense.
David Urdal: I think there are two things on progression that we learned in that study. Progression was occurring much more rapidly in asymptomatic population than we expected. Going into this, our key opinion leaders thought that in asymptomatic patients progression was occurring more slowly than it would it more symptomatic patients and we learned that that’s simply not true, they’re progressing in 12 to 14 weeks, which is just as quickly as they’re progressing later in the disease. The second thing that we learned is that we were not able to show an impact on time to disease progression in the way that we measured it, which was the time to the next progression event or two lesions in the bone. And so if the question is how can you have a drug that has an impact on survival but you don’t see an impact on progression, my belief would be that if we were measuring progression in a more continuous way you might expect to see an impact on the rate of progression. We just weren’t able to measure it.
Matt Herper: So you think the difference is in how the measurement was made, you don’t think it’s revealing differences in the biology?
David Urdal: No. I think you’re seeing support for that idea come out of the other immunotherapies in the last year or so, Prostvac when that was published last summer, same thing, and then ipilimumab [Yervoy, from Bristol-Myers Squibb]. You’re seeing drugs that are being described as having a delayed effect, and meanwhile you’ve got the cancer that continues to progress. So if you’re looking at time to next progression event you might not have a window of time long enough to have an impact on that particular measurement.

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MCO 35.63 +1.31
Chart for Moody's Corporation Common Stoc
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, On Wednesday August 3, 2011, 5:44 pm EDT
BOSTON (AP) -- What relief rally? Hope that the stock market would surge on news of Washington's debt ceiling deal has given way to pessimism. Increasingly defensive-minded investors are adapting to the reality that the economic recovery is stalling, if not ending.
Stocks rose slightly on Wednesday to snap an eight-day string of declines that sent prices down nearly 7 percent.
That stumble complicates matters for investors who recently pulled cash from the market, fearing a government default was a strong possibility. With that worry behind, the question is what to do next.
Richard Shortt had expected to be buying stocks, putting his sidelined money back to work. Yet he was at his home computer Wednesday, selling some of his stocks, and trimming investments in stock mutual funds. The 66-year-old from Somerville, Mass. put the proceeds into safer money-market mutual funds -- the same actions he took last week, when he sold stocks before Congress and President Obama reached the debt ceiling deal.
Shortt kept selling because he worries there's a growing risk that the economy will slip back into recession. He notes the debt deal emphasizes spending cuts, without revenue increases, or stimulus spending that he believes is needed to create jobs.
"It just doesn't seem like a formula for very happy times, for a long, long time," says Shortt, a semi-retired small business consultant. "I'm preparing for a long downturn, but leaving options open, to see if things do change."
President Obama's spokesman said Wednesday that the administration doesn't believe there's a risk that the economy will head back into a recession.
But investors like Shortt have become more cautious in response to troubling news, such as Tuesday's report that consumers cut spending in June for the first time in nearly two years. A weak manufacturing report came out a day earlier, and the government last week said the economy's growth in the first half of this year was the weakest since the recession ended in June 2009. Another influential report is due Friday, when the government will release its employment data for July, which will include the unemployment rate and number of jobs created.
Yet some sense an opportunity. The market research firm Birinyi Associates on Wednesday said that market indicators it tracks suggest stock prices could be set to rebound. Birinyi said too many investors have left prematurely, which creates an opportunity for buyers.
Still, many are anxious:
--Stocks: The Dow Jones industrial average on Wednesday finished up 0.3 percent. But it was down most of the day, which put the market at risk of posting its longest losing streak since 1978, the last time there were nine daily declines in a row.
After the recent losses, a broader stock index, the Standard & Poor's 500, is almost exactly where it started the year.
Investors withdrew a net of nearly $8.8 billion from stock mutual funds during the week that ended last Wednesday, according to the Investment Company Institute. Investors also pulled money from international stocks funds, withdrawing a net $1.3 billion.
--Gold: Prices hit a new record on Wednesday, not adjusted for inflation, topping $1,670 an ounce. Gold prices have risen nearly 13 percent since July 1, and have steadily risen since the start of 2009, when an ounce of gold sold for $880.
Investors believe gold is safe because it tends to hold its value when stocks are falling, and often rises when the dollar falls in value against other currencies, as it did Wednesday.
HSBC precious metals analyst James Steel said in a report that gold's continued rise after the debt deal was reached indicates the rally "is clearly supported by more than just the long drawn-out political arguments over the debt ceiling."
--Treasurys: Prices for Treasury bonds have been rising since the debt deal concluded, reflecting greater investor demand for the government IOUs. Their reputation as a safe haven has been renewed now that the government avoided a default. Treasury yields move opposite their prices. On Wednesday, the yield on the 10-year Treasury slipped as low as 2.56 percent, its lowest level since November. That's even though Moody's Investors Service assigned a negative outlook to U.S. debt, but confirmed its AAA rating, for now.
--Money-market mutual funds: Investors had been withdrawing huge sums from these investments a few days ago, but reversed course once the debt ceiling deal was signed into law. Money funds are typically safe places to stash cash, because they invest in only the safest forms of debt securities. But many money funds invest in Treasurys, a fact not lost on investors who withdrew money as the debt ceiling talks stalled. Nearly $122 billion was withdrawn from money funds in the seven-day period that ended Monday, a surge that cut the $2.6 trillion that the funds hold by almost 5 percent, according to Crane Data. But there was a shift on Tuesday with the debt deal's conclusion, with a net $6 billion flowing back in. That new cash suggests investors once again see money funds as safe.
--Volatility: The stock market's fear gauge, formally known as the Chicago Board of Options Exchange's Volatility Index, has risen to levels last seen in August 2010. The VIX, as market pros call it, is up 35 percent over the past eight trading days. In an unusually volatile market, investors are willing to pay hefty premiums for options that offer protection from price swings of stocks in the Standard & Poor's 500 index.
The recent return of volatility worries Harvey Rowen. He's trying to figure out when to shift more money into stocks on behalf of individual investors whose portfolios he manages as CEO of San Francisco-based Starmont Asset Management.
About 80 percent of the clients that Rowen's firm contacted during the debt ceiling debate chose to sell a portion of their stock holdings and leave the money in cash. But Rowen was reluctant Wednesday to move that money back into the market, noting that negative economic reports have offset positive news from the debt deal.
He's considering adding more alternative investments to the portfolios, such as gold and other commodities, but worries they carry big risks as well.
"It's a hard question now what to do," says Rowen. "It's a struggle to find investments that are prudent, and will give our clients a reasonable return....So for now, we're sitting on that cash."
Matt Herper: It’s seems that one aspect therapies is that you would, in theory, really want to use them early in the disease, when tumors are weaker and patients have stronger immune systems. But I don’t know how you do that in prostate cancer. The studies would need to be too big.
Urdal: I think you’re asking a really key question. Because if you went too early you’d had to do a huge study. We are doing a study which is looking at men who have chosen to get a prostatectomy and they get Provenge some weeks in advance of that so that we can better understand the components in the immune system that are being engaged. But if you were to try to [receive FDA approval] it would have to be a huge study because 70 percent of the men are going to be cured with the surgery alone, and then you’d have to follow them for many many years before you could actually measure a clinical outcome. But we’re having with regulatory agencies in Europe and here in the United States about going into androgen-dependent prostate cancer that is metastatic at the time of diagnosis. The idea is and belief is that the earlier that we go the better the benefit.
Forbes: Last question: Why is the drug business in such a profound innovation drought? Why aren’t drug companies inventing more drugs?
Urdal: It’s something that I worry a lot about and from a slightly different point of view. Look at the dilemma that the venture capital community has. It’s a question of where does the capital come from to actually invest in the companies like the ones that I’ve been associated with. I don’t think there’s any way Immunex could go public today with the evidence it had to go public when it did, or Dendreon for that matter as we were starting our phase 3 program and went public. I think you need to be to the point of having complete clinical validation before you can expect an IPO to go out. So I think the dynamics have really changed. The horizon for VC funds is 10 years and the hurdle of having a body of data that you could go public on has only gotten higher. So where does the Dendreon come from, where does it get its capital? How do those early years get funded for the system to work? Because I worry a lot who’s going to be developing the drugs that are going to be of benefit for my granddaughter, they need to start now because it’s going to be 30 years down the road.

David Urdal: Of the four votes against approval at that time, two were members of the Oncology Drugs Advisory Committee] that had been invited to participate in the meeting. And it was clear, when I look?
A. TRUE
B. FALSE

Immunex could go public today with the evidence it had to go public when it did, or Dendreon for that matter as we were starting our phase 3 program and went public?
A. TRUE
B. FALSE

English Lessons












Monday, August 1, 2011

English Lessons

DIRECTIONS: Read the following and answer all the questions?
http://www.americanenglishconversation.com/
http://www.freeenglishconversation.blogspot.com/
http://www.grammar-help.blogspot.com/

http://freeenglishlessons-denise.blogspot.com/
NEW YORK (AP) -- Stocks wavered between slight gains and losses Tuesday after the Dow Jones industrial average had its best week in two years.
The Dow Jones industrial average slipped 2 points to 12,580 in afternoon trading. The Dow had risen as many as 19 points after the Commerce Department reported an increase in factory orders. The Standard & Poor's 500 index fell 2, or 0.2 percent, to 1,338. The Nasdaq composite index rose 4, or 0.2 percent, to 2,820. All three indexes were moving in a narrow range.
Trading volume is expected to be light this week. U.S. markets were closed Monday for the July 4th holiday. Many traders are looking ahead to next week, when aluminum maker Alcoa Inc. becomes the first major U.S. company to report financial results.
Last week the Dow rose 648 points, its best week in two years, after Nike reported strong earnings and Greece cleared its final hurdle before receiving another round of loans. Automakers also reported that their sales rose 7 percent in June, compared to a year ago.
The gains erased nearly six weeks of losses. Prior to last week stocks had been falling since late April because of concerns about the debt crisis in Europe, weak home sales in the U.S. and slowing manufacturing. By mid-June, stocks had given up most of their gains for the year.
With last week's rally, the Dow is now down just 1.8 percent from April 29, when it reached a three-year high. The Dow is up 8.5 percent for the year. The S&P 500 index and the Nasdaq composite are both up about 6 percent.
Analysts are optimistic about the corporate earnings reports that will start to come in next week. Earnings from companies in the S&P 500 index are expected to rise 14 percent from the same period a year ago, according to FactSet. Revenue is expected to rise 11 percent.
"There hasn't yet really been a reason to get concerned about corporate America," said Randy Warren, chief investment officer of Warren Financial Service. "It's the rest of the America that's struggling."
Even while companies have been reporting higher profits, unemployment has remained stubbornly high since the recession officially ended in June 2009. The Labor Department will report the latest figures on unemployment and payrolls on Friday, and analysts expect to hear more bad news. They forecast that the unemployment rate will remain unchanged from May at 9.1 percent. They also expect that employers added only 90,000 jobs last month, below the 100,000 threshold that economists say is needed to prevent the unemployment rate from increasing.
Several stocks rose sharply after deals were announced. Immucor Inc. rose 30 percent after the maker of blood-testing equipment agreed to be bought by private-investment firm TPG Capital in a deal worth $1.97 billion.
Southern Union Co. rose 2.9 percent after Energy Transfer Equity LP said it would pay $5.1 billion for the pipeline company. The deal trumped a $4.9 billion bid made in late June by rival Williams Cos.
Netflix Inc. rose 7.4 percent to $287.85 after announcing that it would expand its online video streaming service to 43 countries in Latin America and the Caribbean.

Stocks wavered between slight gains and losses Tuesday after the Dow Jones industrial average had its best week in two years?
A. TRUE
B. FALSE

Southern Union Co. rose 2.9 percent after Energy Transfer Equity LP said it would pay $5.1 billion for the pipeline company. The deal trumped a $4.9 billion bid made in late June by rival Williams Cos?
A. TRUE
B. FALSE
, On Friday July 29, 2011, 12:32 am EDT
WASHINGTON (AP) -- The economy likely grew in the first half of the year at the slowest pace since the recession ended, and the second half isn't looking much better.
Weak consumer spending, dismal hiring and cuts in government spending likely held back growth in the April-June quarter. The government will report on second-quarter growth on Friday.
Economists forecast the economy expanded at an annual rate of 1.7 percent, according to a FactSet survey. That follows a 1.9 percent growth rate in the first three months of the year. Those are the slowest back-to-back quarters since the economy began recovering from the recession two years ago.
Even if the economy picks up later this year, growth in 2011 will likely be slower than the 2.9 percent expansion last year. Economists at RBC Capital Markets, for example, forecast growth of 2.3 percent this year.
Complicating an already-weak economy is the debt crisis in Washington. No matter what lawmakers do to resolve that crisis, their decision will likely slow growth in the short term. A deal to raise the borrowing limit would likely include long-term spending cuts, which would withdraw government stimulus at a precarious time. If Congress fails to raise the borrowing limit and the government defaults on its debt, financial markets could fall and interest rates could rise.
Most economists expect growth to pick up slightly in the second half of the year, as the impact of high gas prices and supply disruptions stemming from Japan's March 11 earthquake ease. But growth won't be strong enough to lower the unemployment rate, now 9.2 percent.
"We're starting off the quarter in weaker shape than we thought," said Nigel Gault, an economist at IHS Global Insight. Gault notes that data for June showed little growth in retail sales, factory output and hiring.
Gault said he expects growth of less than 3 percent in the July-September quarter. That's down from his earlier forecast of 3.4 percent. Economists at Goldman Sachs and JPMorgan Chase project third-quarter growth of only 2.5 percent. That's barely enough to keep the unemployment rate from rising.
The economy needs to expand at a 5 percent pace to make a significant dent in unemployment.
Economists cite several reasons for the disappointing growth:
-- Weak consumer spending. Held back by stagnant wages and high unemployment, people simply aren't spending money. Economists forecast that consumer spending grew in the April-June period less than 1 percent, the slowest pace since the recession ended. High gas prices forced consumers to cut back on other discretionary purchases. Sales of furniture, appliances, sporting goods and electronics fell last month for the third straight month, according to the government's June report on retail sales.
-- Cuts in government spending. Governments at all levels -- federal, state and local -- are short on cash and being forced to rein in spending. All told, the cutbacks reduced economic growth 1.2 percentage points in the January-March quarter, the biggest hit to the economy from reduced government spending since the early 1980s. While the impact won't be as large in the April-June period, economists expect lower government spending restrained growth.
-- Dismal hiring. Employers added only 18,000 jobs in June, the second-straight month of weak hiring and much slower than the average of 215,000 jobs added each month from February to April. And even people with jobs aren't getting any raises. Adjusted for inflation, average hourly pay fell 1.5 percent in the past year, the Labor Department said earlier this month.
One wild card for Friday's report on the economy will be how much companies added to their stockpiles. If companies built up more inventory in their warehouses than economists forecast, that would mean factories produced more and the economy grew at a faster pace. But that could also mean slower growth in subsequent months, because consumers aren't spending much and it would take time for companies to reduce their stockpiles. That would slow the production of new goods.